منابع مشابه
Cross-Talk in Cell Death Signaling
Apoptotic cell suicide can be initiated by a plethora of stimuli that generally feed into one of two known cell death signaling pathways (Fig. 1; for review see references 1 and 2). Both pathways share many features, including molecular devices that spark caspase activation by proenzyme recruitment, oligomerization, and proximity-induced auto-catalytic activation. Beyond this, however, their ac...
متن کاملCell Death Signaling and Anticancer Therapy
For a long time, it was commonly believed that efficient anticancer regimens would either trigger the apoptotic demise of tumor cells or induce a permanent arrest in the G(1) phase of the cell cycle, i.e., senescence. The recent discovery that necrosis can occur in a regulated fashion and the increasingly more precise characterization of the underlying molecular mechanisms have raised great int...
متن کاملOverview of cell death signaling pathways.
Apoptosis plays an important role in development and maintenance of tissue homeostasis. Intensive efforts have been made to explore the molecular mechanisms of the apoptotic signaling pathways including the initiation, mediation, execution and regulation of apoptosis. Caspases are central effectors of apoptosis. Cells undergo apoptosis through two major pathways, namely the extrinsic pathway (d...
متن کاملMessengers of cell death: apoptotic signaling in health and disease.
BACKGROUND AND OBJECTIVES Apoptosis is a genetically controlled mechanism of cell death involved in the regulation of tissue homeostasis. Understanding the molecular basis of apoptosis signaling may reveal novel clues for lymphomagenesis. EVIDENCE AND INFORMATION SOURCES Pro-apoptotic signaling is mediated by specific ligands and surface death receptors (extrinsic pathway of apoptosis regulat...
متن کاملJNK-signaling: A multiplexing hub in programmed cell death
Jun N-terminal kinases or JNKs have been shown to be involved in a wide array of signaling events underlying tumorigenesis and tumor progression. Through its interaction with a diverse set of signaling proteins and adaptors, JNKs regulate cell proliferation, invasive migration, therapy resistance, and programmed cell death. JNKs have been shown to play a role in apoptotic as well as non-apoptot...
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ژورنال
عنوان ژورنال: Cold Spring Harbor Perspectives in Biology
سال: 2015
ISSN: 1943-0264
DOI: 10.1101/cshperspect.a006080